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The Phase 1 clinical study of VIT-2763 demonstrated that serum iron levels and transferrin saturation declined transiently, and no obvious safety concerns were identified ( Targeting the hepcidin-ferroportin axis offers a novel therapeutic direction for patients with -thalassemia, particularly for those with NTDT, as it not only reduces iron overload but also improves anemia, decreases ineffective erythropoiesis, and alleviates splenomegaly